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Article

Non-causal association between α-klotho and human lifespan: evidence from multi-omics insights

2025-02-10

Abstract excerpt

While genetic evidence robustly associates longevity in non-human primates with Klotho protein, such a direct correlation in humans remains elusive. To scrutinize the potential causal link between genetically predicted Klotho levels and human lifespan, we devised a meticulous two-sample Mendelian randomization (MR) analysis, just leveraging single nucleotide polymorphisms (SNPs) from genome-wide association studie...

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Literature Corpus work
036f9179-1cad-5a46-a8bf-69ba9c5e2b6c
DOI
10.1101/2025.02.08.25321911
Open publication

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Non-causal association between α-klotho and human lifespan: evidence from multi-omics insightsDOI 10.1101/2025.02.08.25321911
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