Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Klotho: An Elephant in Aging Research

7 Mar 2019

Abstract excerpt

The year 2017 marked the 20th anniversary of the first publication describing Klotho. This single protein was and is remarkable in that its absence in mice conferred an accelerated aging, or progeroid, phenotype with a dramatically shortened life span. On the other hand, genetic overexpression extended both health span and life span by an impressive 30%. Not only has Klotho deficiency been linked to a number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Kidney Cyst Diseases
Share to Genetic Syndromes and Imprinting
Share to Parathyroid Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30843026
DOI: 10.1093/gerona/glz061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Klotho: An Elephant in Aging ResearchPMID 30843026Read ↗

Klotho and the aging process.Semantic proximity Read ↗

Suppression of Aging in Mice by the Hormone KlothoSemantic proximity Read ↗

Klotho and aging.Semantic proximity Read ↗

Klotho: a fundamental regulator of aging.Semantic proximity Read ↗

Klotho protein: a multifaceted regulator in aging and cancer dynamicsSemantic proximity Read ↗

Molecular Basis of Klotho: From Gene to Function in AgingSemantic proximity Read ↗

Aging-suppressor Klotho: Prospects in diagnostics and therapeuticsSemantic proximity Read ↗

Toward a better understanding of Klotho.Semantic proximity Read ↗

Klotho and the Treatment of Human MalignanciesSemantic proximity Read ↗

The Antisenescence Protein Klotho Is Necessary for FGF23-Induced PhosphaturiaSemantic proximity Read ↗

Role of Klotho in the Development of Essential Hypertension.Semantic proximity Read ↗

Role of Exercise on S-Klotho Protein Regulation: A Systematic ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.