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GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating α-Klotho levels

15 Sept 2021

Abstract excerpt

The protein α-Klotho acts as transmembrane co-receptor for fibroblast growth factor 23 (FGF23) and is a key regulator of phosphate homeostasis. However, α-Klotho also exists in a circulating form, with pleiotropic, but incompletely understood functions and regulation. Therefore, we undertook a genome-wide association study (GWAS) meta-analysis followed by Mendelian randomization (MR) of circulating α-Klotho...

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PMID: 34542150
DOI: 10.1093/hmg/ddab263

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