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Article

Plasma Klotho and Mortality Risk in Older Community-Dwelling Adults

7 Apr 2011

Abstract excerpt

BACKGROUND: The aging-suppressor gene klotho encodes a single-pass transmembrane protein that in mice is known to extend life span when overexpressed and resemble accelerated aging when expression is disrupted. It is not known whether there is a relationship between plasma levels of secreted klotho protein and longevity in humans. METHODS: We measured plasma klotho in 804 adults, greater than or equal to 65...

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PMID: 21474560
DOI: 10.1093/gerona/glr058

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