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Aging-suppressor Klotho: Prospects in diagnostics and therapeutics

22 Oct 2022

Abstract excerpt

INTRODUCTION: The protein Klotho (KL) was first discovered in KL-deficient mice, which developed a syndrome similar to premature aging in humans. Since then, KL has been implicated in multiple molecular signaling pathways and diseases. KL has been shown to have anti-aging, healthspan and lifespan extending, cognitive enhancing, anti-oxidative, anti-inflammatory, and anti-tumor properties. KL levels decrease with...

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PMID: 36283617
DOI: 10.1016/j.arr.2022.101766

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