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Article

Genetically determined α-Klotho levels and causal association with aging-related lung diseases.

Respiratory medicine - 1 May 2025

Jin Chen, Jin Ruiying, Liu Dingyu, Li Yuwen

Abstract excerpt

BACKGROUND: Abnormal α-Klotho (KL) levels play an essential role in the pathogenesis of aging-related lung diseases. However, the correlation between circulating KL levels and aging-related lung diseases has not been determined. This study aimed to determine whether circulating KL levels causally affect aging-related lung diseases using Mendelian randomization (MR). METHODS: Five KL-associated Single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40180194
DOI: 10.1016/j.rmed.2025.108081

Genes

KL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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