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Article

Circulating α-Klotho Levels in Relation to Cardiovascular Diseases: A Mendelian Randomization Study.

Frontiers in endocrinology - 1 Jan 2022

Sun Xingang, Chen Lu, He Yuxian, Zheng Liangrong

Abstract excerpt

Background: Several studies have reported a protective role of circulating α-Klotho on cardiovascular diseases (CVD); however, the causality remains unclear. We aim to elucidate whether genetically predicted circulating α-Klotho levels were causally associated with the risk of coronary artery disease (CAD), atrial fibrillation (AF), heart failure (HF), stroke, ischemic stroke (IS), and IS subtypes. Methods: A...

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Identifiers

PMID: 35197934
DOI: 10.3389/fendo.2022.842846
PMCID: PMC8859151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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