Article

Epigenomic regulatory programs reveal the latent heterogeneity of complex diseases

2026-05-05

Abstract excerpt

<h4>Summary</h4> Complex diseases exhibit substantial variation in clinical presentation and outcome despite shared diagnoses. Current genetic models typically represent inherited risk as a single additive liability, obscuring the diverse biological mechanisms through which variants influence disease. Here, we show that disease-associated variants are organized into recurrent regulatory programs that reveal laten...

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Literature Corpus work: da31c671-a66f-5899-bb6a-b7a1d6ed1155
DOI: 10.64898/2026.05.01.722123

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