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Article

Genetic effects on chromatin accessibility uncover mechanisms of liver gene regulation and quantitative traits.

Genome research - 1 Jul 2025

Currin Kevin W, Perrin Hannah J, Pandey Gautam K, Alkhawaja Abdalla A, Vadlamudi Swarooparani, Musser Annie E, Etheridge Amy S, Broadaway K Alaine, Rosen Jonathan D, Varshney Arushi, Chaudhry Amarjit S, Gallins Paul J, Wright Fred A, Zhou Yi-Hui, Parker Stephen C J, Raffield Laura M, Schuetz Erin G, Innocenti Federico, Mohlke Karen L

Abstract excerpt

Chromatin accessibility quantitative trait locus (caQTL) studies have identified regulatory elements that underlie genetic effects on gene expression and metabolic traits. However, caQTL discovery has been limited by small sample sizes. Here, we map caQTLs in liver tissue from 138 human donors and identify caQTLs for 35,361 regulatory elements, including population-specific caQTLs driven by differences in allele...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 40393811
DOI: 10.1101/gr.279741.124
PMCID: PMC12212085

Genes

RALGPS2
TENM2

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