Article

Programmed inhibition of an innate immune receptor via <i>de novo</i> designed transmembrane proteins

2025-05-31

Abstract excerpt

Transmembrane domains of immune complexes transmit precise signals across lipid bilayers. Probing their interactions has the potential to yield mechanistic insights relevant to therapeutic design. However, our capability to generate molecules directed to bind lipid-embedded sites is limited. Here, we demonstrate a computational strategy to design polypeptides targeting Toll-like receptor 4 (TLR4), a mediator of in...

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Identifiers and source

Literature Corpus work: 0355e774-d86b-5fb0-abf9-30975a59ccf7
DOI: 10.1101/2025.05.31.657109

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