Article

Allosteric Inhibition of the T Cell Receptor by a Designed Membrane Ligand

2022-08-20

Abstract excerpt

The T cell receptor (TCR) is a complex molecular machine that directs the activation of T cells, allowing the immune system to fight pathogens and cancer cells. Despite decades of investigation, the molecular mechanism of TCR activation is still controversial. One of the leading activation hypotheses is the allosteric model. This model posits that binding of pMHC at the extracellular domain triggers a dynamic chan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da19a492-232c-5953-866e-a72f0068ad3f
DOI: 10.1101/2022.08.19.503518

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Allosteric Inhibition of the T Cell Receptor by a Designed Membrane LigandDOI 10.1101/2022.08.19.503518Read

TCR3d: The T cell receptor structural repertoire databaseSemantic proximity Read

GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeuticsSemantic proximity Read

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read

Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling.Semantic proximity Read

The T-cell-receptor signaling networkSemantic proximity Read

Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipidSemantic proximity Read

AI-Driven Design of Nanobinders Targeting the TSLPR Heterodimer Interface to Suppress Type 2 Inflammatory SignalingSemantic proximity Read

Programmed inhibition of an innate immune receptor via <i>de novo</i> designed transmembrane proteinsSemantic proximity Read

CD8 Binding of MHC-Peptide Complexes in cis or trans Regulates CD8+ T-cell Responses.Semantic proximity Read

A novel peptide that disrupts the Lck-IP3R protein-protein interaction induces widespread cell death in leukemia and lymphomaSemantic proximity Read

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthmaSemantic proximity Read