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Coordinated Tuning of Ionizable Lipids and Formulation Redirects mRNA Vaccines Toward Lymphoid-Specific CD4 <sup>+</sup> T Cell Immunity

2026-04-18

Abstract excerpt

The global success of mRNA vaccines has underscored the pivotal role of lipid nanoparticles (LNPs), yet how subtle chemical variations in ionizable lipids and their formulation parameters orchestrate complex immune landscapes remains largely elusive. Here, we report a novel ionizable lipid, N4Z, and demonstrate that its distinct chemical signature selectively intensifies early innate immune programs compared to it...

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Literature Corpus work
f2538f45-65dd-53dd-95ff-9a3bc1b719ca
DOI
10.64898/2026.04.16.719092
Open publication

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Coordinated Tuning of Ionizable Lipids and Formulation Redirects mRNA Vaccines Toward Lymphoid-Specific CD4 <sup>+</sup> T Cell ImmunityDOI 10.64898/2026.04.16.719092
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