Article

Intrinsically disordered ligands for the control of receptor uptake by endocytosis

2026-04-08

Abstract excerpt

Endocytosis plays a crucial role in signaling, recycling, and degradation of receptors. Controlling endocytosis of specific receptors is therefore a major goal for both basic science and medicine. While antibody-induced dimerization can drive signaling-induced uptake of some receptors, the steric bulk of antibodies generally inhibits endocytosis, such that control over receptor uptake remains an unmet need. Recent...

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Literature Corpus work: 69f7e873-703c-5b44-8373-47f8e0eeca9c
DOI: 10.64898/2026.04.06.716760

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