Article

Tuning Insulin Receptor Signaling Using <i>De Novo</i> Designed Agonists

2024-10-11

Abstract excerpt

<h4>Summary</h4> Binding of insulin to the insulin receptor (IR) induces conformational changes in the extracellular portion of the receptor that lead to activation of the intracellular kinase domain and the AKT and MAPK pathways, and downstream modulation of glucose metabolism and cell proliferation. We reasoned that designed agonists that induce different conformational changes in the receptor might induce diff...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ce31e6f-248e-53e0-93e1-d4a5fc8503f7
DOI: 10.1101/2024.10.07.617068

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tuning Insulin Receptor Signaling Using <i>De Novo</i> Designed AgonistsDOI 10.1101/2024.10.07.617068Read

Reprogramming insulin receptor activation with a de novo agonist to overcome severe insulin resistanceSemantic proximity Read

Designing Insulin Analogues with Lower Binding Affinity to Insulin Receptor than That of Insulin IcodecSemantic proximity Read

Insulin receptor activation with transmembrane domain ligands.Semantic proximity Read

Mapping Structural Drivers of Insulin Analogs Using Molecular Dynamics and Free Energy Calculations at Insulin ReceptorSemantic proximity Read

Structure-Based Computational Analysis of Interactions between Insulin Receptor and Insulin Inhibitory ReceptorSemantic proximity Read

Structural basis of insulin receptor antagonism by bivalent site 1-site 2 ligandsSemantic proximity Read

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistanceSemantic proximity Read

Structural Dynamics of Insulin Receptor and Transmembrane Signaling.Semantic proximity Read

Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor.Semantic proximity Read

Blind De Novo Design of Dual Cyclic Peptide Agonists Targeting GCGR and GLP1RSemantic proximity Read

How Structural Modifications of Insulin Icodec Contributes to Its Prolonged Duration of Action: A Structural and Biophysical PerspectiveSemantic proximity Read

Focus issue: Cracking the G protein-coupled receptor code.Semantic proximity Read