Article

Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cells

2021-05-23

Abstract excerpt

<h4>SUMMARY</h4> Synthetic biology has established powerful tools to precisely control cell function. Engineering these systems to meet clinical requirements has enormous medical implications. Here, we adopted a clinically driven design process to build receptors for the autonomous control of therapeutic cells. We examined the function of key domains involved in regulated intramembrane proteolysis and showed that...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2656af88-8fd1-5456-88aa-f528b0364338
DOI: 10.1101/2021.05.21.445218

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Design and modular assembly of synthetic intramembrane proteolysis receptors for custom gene regulation in therapeutic cellsDOI 10.1101/2021.05.21.445218Read

Synthetic Hybrid Receptors for Safer and Programmable T Cell TherapySemantic proximity Read

Programmable synthetic receptors: the next-generation of cell and gene therapiesSemantic proximity Read

Synthetic Cytosolic Splicing Enables Programmable mRNA-Encoded ReceptorsSemantic proximity Read

Transitioning from native to synthetic receptors: broadening T-cell engineering and beyondSemantic proximity Read

Engineering synthetic phosphorylation signaling networks in human cellsSemantic proximity Read

Programming cell behavior with synthetic protease-activated receptorsSemantic proximity Read

Clinically-driven design of synthetic gene regulatory programs in human cellsSemantic proximity Read

Engineering of extracellular vesicles for display of protein biotherapeuticsSemantic proximity Read

Extracellular Ligand-Responsive Translational Regulation of Synthetic mRNAs using Engineered ReceptorsSemantic proximity Read

Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuliSemantic proximity Read

Protease-controlled secretion and display of intercellular signals.Semantic proximity Read

Pharmacologically regulated bioorthogonal stabilization domain for regulation of CAR T cellsSemantic proximity Read