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Mechanism of host cell invasion by <i>Leishmania</i> through KMP-11 mediated cholesterol-transport and membrane phase transition

2024-07-17

Abstract excerpt

The first step of successful infection by any intracellular pathogen relies on its ability to invade its host cell membrane. However, the detailed structural and molecular understanding underlying lipid membrane modification during pathogenic invasion remains unclear. In this study, we show that a specific Leishmania donovani (LD) protein, KMP-11, forms oligomers that bridge LD and host macrophage (MΦ) membranes....

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Literature Corpus work
d66c3233-e940-5486-b2a4-5c9556495614
DOI
10.1101/2024.07.15.603533
Open publication

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Mechanism of host cell invasion by <i>Leishmania</i> through KMP-11 mediated cholesterol-transport and membrane phase transitionDOI 10.1101/2024.07.15.603533
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