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In vitro and in vivo evaluation of chemically synthesized, receptor-biased interleukin-4 and photocaged variants

25 Jun 2025

Abstract excerpt

Interleukin-4 (IL-4) plays a central role in type 2 immune responses. Despite its potential use for allergic and autoimmune diseases, its pleiotropic receptor binding complicates selective targeting of IL-4 signaling pathways. We developed a chemical synthesis of (i) IL-4 variants with atomically tailored side-chain modifications that deter specific receptor interactions and (ii) conditionally activatable IL-4...

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PMID: 40561016
DOI: 10.1126/sciadv.adw9755

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