Article

Programmable synthetic cytokine receptors polarize macrophages to user-defined functional states

2026-05-12

Abstract excerpt

<h4>Summary</h4> Technology that precisely controls macrophage polarization to distinct functional states would deepen our understanding of macrophage biology and enable the development of new macrophage cell therapies. Here, we use a synthetic cytokine receptor (SCR) platform with a programmable signaling domain to control the polarization of primary human macrophages. SCRs containing signaling motifs from the i...

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Literature Corpus work: 8d2ccab8-ded9-5dbe-89e4-c74d216d1e96
DOI: 10.64898/2026.05.12.724672

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