Article

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence

2020-09-27

Abstract excerpt

Quiescence, an actively-maintained reversible state of cell cycle arrest, is not well understood. PTEN is one of the most frequently lost tumor suppressors in human cancers and regulates quiescence of stem cells and cancer cells. In C. elegans mutant for daf-18 , the sole C. elegans PTEN ortholog, primordial germ cells (PGCs) divide inappropriately in starvation conditions, in a TOR-dependent manner. Here, we f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 034fe712-9658-576f-a454-9f5c71292524
DOI: 10.1101/2020.09.27.314948

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescenceDOI 10.1101/2020.09.27.314948Read

Genetic analysis of DAF-18/PTEN missense mutants for the ability to maintain quiescence of the somatic gonad and germ line in Caenorhabditis elegans dauer larvae.Semantic proximity Read

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background.Semantic proximity Read

Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.Semantic proximity Read

C. elegans AMPKs promote survival and arrest germline development during nutrient stressSemantic proximity Read

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistanceSemantic proximity Read

DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferationSemantic proximity Read

Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling.Semantic proximity Read

Insulin signaling promotes germline proliferation in C. elegans.Semantic proximity Read

Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans.Semantic proximity Read

Reproductive aging in invertebrate genetic modelsSemantic proximity Read

Controls of Germline Stem Cells, Entry into Meiosis, and the Sperm/Oocyte Decision in<i>Caenorhabditis elegans</i>Semantic proximity Read

PUF-8, a Pumilio homolog, inhibits the proliferative fate in the Caenorhabditis elegans germline.Semantic proximity Read