Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans.

The EMBO journal - 9 Apr 2008

Watanabe Sonoko, Yamamoto Takaharu G, Kitagawa Risa

Abstract excerpt

When newly hatched Caenorhabditis elegans larvae are starved, their primordial germ cells (PGCs) arrest in the post-S phase. This starvation-induced PGC arrest is mediated by the DAF-18/PTEN-AKT-1/PKB nutrient-sensing pathway. Here, we report that the conserved spindle assembly checkpoint (SAC) component MDF-1/MAD1 is required for the PGC arrest. We identified 2 Akt kinase phosphorylation sites on MDF-1....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Food
Share to Food Deprivation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Proto-Oncogene Proteins c-akt

Share to Spindle Apparatus

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 18309291
DOI: 10.1038/emboj.2008.32
PMCID: PMC2323251

Genes

PGC
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans.PMID 18309291Read ↗

C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.Semantic proximity Read ↗

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.Semantic proximity Read ↗

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.Semantic proximity Read ↗

Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.Semantic proximity Read ↗

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescenceSemantic proximity Read ↗

Activated AKT/PKB signaling in C. elegans uncouples temporally distinct outputs of DAF-2/insulin-like signaling.Semantic proximity Read ↗

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background.Semantic proximity Read ↗

C. elegans AMPKs promote survival and arrest germline development during nutrient stressSemantic proximity Read ↗

Prolonged quiescence delays somatic stem cell-like divisions in Caenorhabditis elegans and is controlled by insulin signaling.Semantic proximity Read ↗

C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosisSemantic proximity Read ↗

Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation.Semantic proximity Read ↗

Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle controlSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.