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DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation

14 Apr 2017

Abstract excerpt

Under replete growth conditions, abundant nutrient uptake leads to the systemic activation of insulin/IGF-1 signalling (IIS) and the promotion of stem cell growth/proliferation. Activated IIS can stimulate the ERK/MAPK pathway, the activation of which also supports optimal stem cell proliferation in various systems.Stem cell proliferation rates can further be locally refined to meet the resident tissue's need for...

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PMID: 28410423
DOI: 10.1371/journal.pgen.1006738

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