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Article

Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling.

Development (Cambridge, England) - 1 Feb 2006

Narbonne Patrick, Roy Richard

Abstract excerpt

In C. elegans, reduced insulin-like signalling induces developmental quiescence, reproductive delay and lifespan extension. We show here that the C. elegans orthologues of LKB1 and AMPK cooperate during conditions of reduced insulin-like signalling to establish cell cycle quiescence in the germline stem cell population, in addition to prolonging lifespan. The inactivation of either protein causes aberrant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16407400
DOI: 10.1242/dev.02232

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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