Insulin signaling promotes germline proliferation in C. elegans.

doi:10.1242/dev.042523

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Article

Insulin signaling promotes germline proliferation in C. elegans.

Development (Cambridge, England) - 1 Feb 2010

Michaelson David, Korta Dorota Z, Capua Yossi, Hubbard E Jane Albert

Abstract excerpt

Cell proliferation must be coordinated with cell fate specification during development, yet interactions among pathways that control these two critical aspects of development are not well understood. The coordination of cell fate specification and proliferation is particularly crucial during early germline development, when it impacts the establishment of stem/progenitor cell populations and ultimately the...

Topics

Animals
Animals, Genetically Modified
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Differentiation
Cell Proliferation
Cytokines
Female
Forkhead Transcription Factors
Genes, Helminth
Germ Cells
Insulin
Larva
Ligands
Male

Source

Open in PubMed Open full text

Identifiers

PMID: 20110332
DOI: 10.1242/dev.042523
PMCID: PMC2827619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Phenotype

Phosphatidylinositol 3-Kinases

Receptor, Insulin