Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background.

Experimental gerontology - 1 Aug 2014

Wolf Tim, Qi Wenjing, Schindler Verena, Runkel Eva Diana, Baumeister Ralf

Abstract excerpt

Managing available resources is a key necessity of each organism to cope with the environment. The nematode C. elegans responds to nutritional deprivation or harsh environmental conditions with a multitude of developmental adaptations, among them a starvation-induced quiescence at early larval development (L1). daf-18, the C. elegans homolog of the human tumor suppressor gene PTEN, is essential for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticarcinogenic Agents
Share to Doxycycline
Share to Energy Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Food Deprivation

Share to G2 Phase Cell Cycle Checkpoints

Share to Neoplasms, Germ Cell and Embryonal

Share to Nutritional Status

Share to Shc Signaling Adaptor Proteins

Source

Identifiers

PMID: 24746511
DOI: 10.1016/j.exger.2014.04.002

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background.PMID 24746511Read ↗

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescenceSemantic proximity Read ↗

C. elegans AMPKs promote survival and arrest germline development during nutrient stressSemantic proximity Read ↗

Starvation protects germline stem cells and extends reproductive longevity in C. elegans.Semantic proximity Read ↗

Non-autonomous PMK-1/p38 MAPK signaling ensures homeostatic downregulation of germline stem cell proliferation in <i>C. elegans</i>Semantic proximity Read ↗

Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegansSemantic proximity Read ↗

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistanceSemantic proximity Read ↗

A Genome-Wide RNAi Screen for Enhancers of a Germline Tumor Phenotype Caused by Elevated GLP-1/Notch Signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Genetic analysis of DAF-18/PTEN missense mutants for the ability to maintain quiescence of the somatic gonad and germ line in Caenorhabditis elegans dauer larvae.Semantic proximity Read ↗

C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line.Semantic proximity Read ↗

Cancer models in Caenorhabditis elegansSemantic proximity Read ↗

Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.Semantic proximity Read ↗

A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.