Article

Inducible estrogen receptor alpha in normal breast epithelial cells demonstrate estrogen receptor-dependent DNA damage

2025-03-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Signaling by estrogen-receptor alpha (ERα) plays a major role in breast cancer initiation Investigations of the mechanism of DNA damage mediated by ERα signaling are carried out in breast cancer cell lines due to the lack of ERα+ normal human breast epithelial cells lines (HBEC). Defining the mechanisms by which ERα induces DNA damage and initiates tumorigenesis requires nor...

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Literature Corpus work: 0345b790-7a57-5e70-88bb-5dfe190dc34f
DOI: 10.1101/2025.03.13.643100

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