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Article

Resistance to endocrine therapy in breast cancer: molecular mechanisms and future goals

1 Nov 2018

Abstract excerpt

INTRODUCTION: The majority of breast cancers (BCs) are characterized by the expression of estrogen receptor alpha (ERα+). ERα acts as ligand-dependent transcription factor for genes associated with cell survival, proliferation, and tumor growth. Thus, blocking the estrogen agonist effect on ERα is the main strategy in the treatment of ERα+ BCs. However, despite the development of targeted anti-estrogen therapies...

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PMID: 30382472
DOI: 10.1007/s10549-018-5023-4

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