Article
Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.
Journal of the National Cancer Institute - 21 Nov 2007
Hosey Alison M, Gorski Julia J, Murray Margaret M, Quinn Jennifer E, Chung Wen Y, Stewart Gail E, James Colin R, Farragher Susan M, Mulligan Jude M, Scott Alistair N, Dervan Peter A, Johnston Patrick G, Couch Fergus J, Daly Peter A, Kay Elaine, McCann Amanda, Mullan Paul B, Harkin D Paul
Abstract excerpt
BACKGROUND: BRCA1-mutant breast tumors are typically estrogen receptor alpha (ER alpha) negative, whereas most sporadic tumors express wild-type BRCA1 and are ER alpha positive. We examined a possible mechanism for the observed ER alpha-negative phenotype of BRCA1-mutant tumors. METHODS: We used a breast cancer disease-specific microarray to identify transcripts that were differentially expressed between...
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