Article

Influence of Estrogen Treatment On ESR1+ and ESR1- Cells In ER+ Breast Cancer: Insights From Single-Cell Analysis of Patient-Derived Xenograft Models

2021-08-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Estrogen typically promotes the progression of hormone-dependent breast cancer through activation of estrogen receptor (ER)-α encoded by <italic>ESR1</italic>. While estrogen-induced tumor suppression in ER<sup>+</sup> breast cancer has been clinically observed as an unexpected outcome of aromatase inhibitor (AI)-resistance, the molecular mechanisms have not yet...

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Literature Corpus work: 4fd68c6f-5b90-5282-8adb-33bd0b9e7333
DOI: 10.21203/rs.3.rs-816591/v1

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