Article

Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer

2023-03-17

Abstract excerpt

<h4>Purpose</h4> Clinical evidence indicates that treatment with estrogens elicits anti-cancer effects in ∼30% of patients with advanced endocrine-resistant estrogen receptor alpha (ER)-positive breast cancer. Despite the proven efficacy of estrogen therapy, its mechanism of action is unclear and this treatment remains under-utilized. Mechanistic understanding may offer strategies to enhance therapeutic efficacy....

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Literature Corpus work: dd9b2850-7060-5811-b11c-cf9a9e8c442c
DOI: 10.1101/2023.03.16.532956

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