Article

Estrogen Receptor Enhancers Sensitive to Low Doses of Hormone Specify Distinct Molecular and Biological Outcomes

2025-08-12

Abstract excerpt

<h4>Summary</h4> Adult women are typically exposed to estradiol (E2) concentrations of ∼100-200 pM, yet most cell-based studies use 100 nM. We determined the molecular effects of E2 concentrations spanning six orders of magnitude (1 pM to 100 nM) in breast cancer cells. Estrogen receptor alpha (ERα) enhancers formed at low physiological doses of E2 (1-100 pM) are mechanistically distinct from those that form at h...

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Literature Corpus work: ae1f6fd5-a368-54a7-a2c6-077d13bd3dd6
DOI: 10.1101/2025.08.08.669412

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