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Mechanisms for estrogen receptor expression in human cancer

19 Sept 2018

Abstract excerpt

Estrogen is a steroid hormone that has critical roles in reproductive development, bone homeostasis, cardiovascular remodeling and brain functions. However, estrogen also promotes mammary, ovarian and endometrial tumorigenesis. Estrogen antagonists and drugs that reduce estrogen biosynthesis have become highly successful therapeutic agents for breast cancer patients. The effects of estrogen are largely mediated...

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PMID: 30250760
DOI: 10.1186/s40164-018-0116-7

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