Article

ERα-LBD, a novel isoform of estrogen receptor alpha, promotes breast cancer proliferation and endocrine resistance

2021-10-15

Abstract excerpt

<h4>ABSTRACT</h4> Estrogen receptor alpha (ERα) drives mammary gland development and breast cancer (BC) growth through an evolutionarily conserved linkage of DNA binding and hormone activation functions. Therapeutic targeting of the hormone binding pocket is a widely utilized and successful strategy for breast cancer prevention and treatment. However, resistance to this endocrine therapy is frequently encountered...

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Literature Corpus work: 93d62897-e5c6-5d8e-adcf-f876920f6c4a
DOI: 10.1101/2021.10.14.464262

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