Article

Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs

2024-07-04

Abstract excerpt

Emerging immunotherapies such as immune checkpoint blockade (ICB) and chimeric antigen receptor T-cell (CAR-T) therapy have revolutionized cancer treatment and have improved the survival of patients with multiple cancer types. Despite this success many patients are unresponsive to these treatments or relapse following treatment. CRISPR activation and knockout (KO) screens have been used to identify novel single ge...

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Literature Corpus work: 0329c83f-4e24-5364-a4a1-8f26be602187
DOI: 10.1101/2024.07.02.601809

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