Article

Th2 single-cell heterogeneity and clonal interorgan distribution in helminth-infected mice

2021-10-03

Abstract excerpt

Th2 cells provide effector functions in type 2 immune responses to helminths and allergens. Despite knowledge about molecular mechanisms of Th2 cell differentiation, there is little information on Th2 cell heterogeneity and clonal distribution between organs. To address this, we performed combined single-cell transcriptome and TCR clonotype analysis on murine Th2 cells in mesenteric lymph nodes (MLN) and lung afte...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 02f92d68-a6d2-5537-a032-f62cb8963381
DOI: 10.1101/2021.10.03.462935

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Th2 single-cell heterogeneity and clonal interorgan distribution in helminth-infected miceDOI 10.1101/2021.10.03.462935Read

Single-cell molecular signature of pathogenic T helper subsets in type 2–associated disorders in humansSemantic proximity Read

Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells.Semantic proximity Read

Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid CellsSemantic proximity Read

Progenitor T cells drive chronic pulmonary type 2 inflammationSemantic proximity Read

Th2 Cells in Health and DiseaseSemantic proximity Read

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective responseSemantic proximity Read

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.Semantic proximity Read

New insights into the function, development, and plasticity of type 2 innate lymphoid cellsSemantic proximity Read

Single-Cell TCR Sequencing Reveals the Dynamics of T Cell Repertoire Profiling During Pneumocystis InfectionSemantic proximity Read

T follicular helper cells differentiate from Th2 cells in response to helminth antigensSemantic proximity Read

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infectionSemantic proximity Read

Heterogeneity of type 2 innate lymphoid cellsSemantic proximity Read