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Article

Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4+ T cells.

Cell reports - 25 Jun 2024

Williams Cameron G, Moreira Marcela L, Asatsuma Takahiro, Lee Hyun Jae, Li Shihan, Barrera Irving, Murray Evan, Soon Megan S F, Engel Jessica A, Khoury David S, Le Shirley, Wanrooy Brooke J, Schienstock Dominick, Alexandre Yannick O, Skinner Oliver P, Joseph Rainon, Beattie Lynette, Mueller Scott N, Chen Fei, Haque Ashraful

Abstract excerpt

Naive CD4+ T cells must differentiate in order to orchestrate immunity to Plasmodium, yet understanding of their emerging phenotypes, clonality, spatial distributions, and cellular interactions remains incomplete. Here, we observe that splenic polyclonal CD4+ T cells differentiate toward T helper 1 (Th1) and T follicular helper (Tfh)-like states and exhibit rarer phenotypes not elicited among T cell receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38848213
DOI: 10.1016/j.celrep.2024.114317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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