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Article

Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection

4 Jan 2018

Abstract excerpt

Both TH2-dependent helminth killing and suppression of the TH2 effector response have been attributed to macrophages (MΦ) activated by IL-4 (M(IL-4)). To investigate how M(IL-4) contribute to diverse infection outcomes, the MΦ compartment of susceptible BALB/c mice and more resistant C57BL/6 mice was profiled during infection of the pleural cavity with the filarial nematode, Litomosoides sigmodontis. C57BL/6 mice...

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PMID: 29299998
DOI: 10.7554/elife.30947

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