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New insights into the function, development, and plasticity of type 2 innate lymphoid cells

7 Oct 2018

Abstract excerpt

Group 2 innate lymphoid cells (ILC2s) are the most well defined group of ILCs. ILC2 development is controlled by the GATA-3 transcription factor and these cells produce archetypal type 2 cytokines, such as IL-5 and IL-13. These cytokines mediate parasite expulsion and tissue repair, but also contribute to type 2 inflammatory diseases, including allergy, asthma and chronic rhinosinusitis with nasal polyps. In...

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PMID: 30294969
DOI: 10.1111/imr.12708

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