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T follicular helper cells differentiate from Th2 cells in response to helminth antigens

20 Apr 2009

Abstract excerpt

The relationship of T follicular helper (TFH) cells to other T helper (Th) subsets is controversial. We find that after helminth infection, or immunization with helminth antigens, reactive lymphoid organs of 4get IL-4/GFP reporter mice contain populations of IL-4/GFP-expressing CD4(+) T cells that display the TFH markers CXCR5, PD-1, and ICOS. These TFH cells express the canonical TFH markers BCL6 and IL-21, but...

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PMID: 19380637
DOI: 10.1084/jem.20090303

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