Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.

Nature immunology - 1 Feb 2021

Kiner Evgeny, Willie Elijah, Vijaykumar Brinda, Chowdhary Kaitavjeet, Schmutz Hugo, Chandler Jodie, Schnell Alexandra, Thakore Pratiksha I, LeGros Graham, Mostafavi Sara, Mathis Diane, Benoist Christophe

Abstract excerpt

CD4+ effector lymphocytes (Teff) are traditionally classified by the cytokines they produce. To determine the states that Teff cells actually adopt in frontline tissues in vivo, we applied single-cell transcriptome and chromatin analyses to colonic Teff cells in germ-free or conventional mice or in mice after challenge with a range of phenotypically biasing microbes. Unexpected subsets were marked by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Infections
Share to Colon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Microbiome

Share to Interferon Regulatory Factors

Share to Intestinal Diseases, Parasitic

Share to Salmonella enterica

Share to Single-Cell Analysis

Share to Transcription Factor AP-1

Source

Open in PubMed Open full text

Identifiers

PMID: 33462454
DOI: 10.1038/s41590-020-00836-7
PMCID: PMC7839314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes.PMID 33462454Read ↗

Tissue-embedded CD4⁺ plasticity defines mucosal immunity in Inflammatory Bowel DiseaseSemantic proximity Read ↗

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokinesSemantic proximity Read ↗

Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac diseaseSemantic proximity Read ↗

Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn’s diseaseSemantic proximity Read ↗

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity Read ↗

The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity Read ↗

Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activationSemantic proximity Read ↗

Pro-inflammatory innate-like T cells are expanded in the blood and inflamed intestine in Crohn’s DiseaseSemantic proximity Read ↗

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responsesSemantic proximity Read ↗

Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactionsSemantic proximity Read ↗

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read ↗

Divergent T Cell Phenotypes Define Pediatric Crohn’s Disease and Ulcerative ColitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.