Article

Heterogeneous Tfh cell populations that develop during enteric helminth infection predict the quality of type 2 protective response

2021-10-21

Abstract excerpt

T follicular helper (Tfh) cells are an important component of the germinal centre (GC)-mediated humoral immunity. Yet, how regulation of Tfh- GC responses impacts on effective responses to helminth infection are poorly understood. Here we show that chronic helminth Trichuris muris infection fails to induce Tfh-GC B cell responses, with Tfh cells expressing T-bet and IFN-γ. In contrast, Tfh cells that express GATA...

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Literature Corpus work: 7f3676fe-e194-5ae5-8a01-b54fb2b6ab62
DOI: 10.1101/2021.10.20.465079

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