Article
Deficits in human trisomy 21 iPSCs and neurons.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 2013
Weick Jason P, Held Dustie L, Bonadurer George F, Doers Matthew E, Liu Yan, Maguire Chelsie, Clark Aaron, Knackert Joshua A, Molinarolo Katharine, Musser Michael, Yao Lin, Yin Yingnan, Lu Jianfeng, Zhang Xiaoqing, Zhang Su-Chun, Bhattacharyya Anita
Abstract excerpt
Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21) in a human genome that enables normal gene regulation. To overcome this limitation, we created Ts21-induced...
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