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Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome

1 Nov 2023

Abstract excerpt

Down syndrome (DS) results from trisomy of human chromosome 21 (HSA21), and DS research has been conducted by the use of mouse models. We previously generated a humanized mouse model of DS, TcMAC21, which carries the long arm of HSA21. These mice exhibit learning and memory deficits, and may reproduce neurodevelopmental alterations observed in humans with DS. Here, we performed histologic studies of the TcMAC21...

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PMID: 38025769
DOI: 10.1016/j.isci.2023.108379

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