Article

scRNA-seq revealed the rules for CDR3 length pairing in TCR beta and alpha chains and BCR heavy and light chains in human and mice

2024-06-02

Abstract excerpt

The binding of T cell receptor (TCR)/B cell receptor (BCR) CDR3 with linear or conformational epitopes is a prerequisite for the adaptive immune response. The rules for CDR3 length pairing and the amino acid (AA) distributions in the prioritized rearrangement of the β chain (or heavy chain) and subsequent rearrangement of the α chain (or light chain) during the process of germline V(D)J gene rearrangement and self...

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Literature Corpus work: 1e7b0de7-e3de-5f42-9472-b504653f8671
DOI: 10.1101/2024.05.28.596201

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