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Article

High-throughput pairing of T cell receptor α and β sequences

19 Aug 2015

Abstract excerpt

The T cell receptor (TCR) protein is a heterodimer composed of an α chain and a β chain. TCR genes undergo somatic DNA rearrangements to generate the diversity of T cell binding specificities needed for effective immunity. Recently, high-throughput immunosequencing methods have been developed to profile the TCR α (TCRA) and TCR β (TCRB) repertoires. However, these methods cannot determine which TCRA and TCRB...

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PMID: 26290413
DOI: 10.1126/scitranslmed.aac5624

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