Genesis of the <i>αβ</i> T-cell receptor

Abstract excerpt

The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called α and β , to recognize pathogens. Using results of high throughput sequencing and computational chain-pairing experiments of human TCR repertoires, we quantitively characterize the αβ generation process. We estimate the probabilities of a rescue recombination of the β chain on the second chromosome upon failure or s...

Topics

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• CAR-T cell therapy research
• Chronic Lymphocytic Leukemia Research
• Cytomegalovirus and herpesvirus research
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

325682d1-74c2-5ecf-a6b1-0d3ee933ff6b

DOI

10.1101/353128