Article

Potent substoichiometric inhibition of alpha-synuclein aggregation by <i>de novo</i> oligomer-binding proteins

2026-07-14

Abstract excerpt

The non-amyloid β component (NAC) domain of alpha synuclein (αSyn) drives αSyn aggregation in Parkinson disease, yet as an intrinsically disordered segment it lacks a stable epitope for conventional ligand discovery. Using deep learning-based protein design, we generated compact single-chain binders that take advantage of the propensity of the NAC domain to adopt an extended β-strand conformation, which they engag...

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Literature Corpus work: 02cb0913-c0b8-5416-a5b3-9fd381237b0a
DOI: 10.64898/2026.07.13.738012

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