Article

Fine-Tuning α-Synuclein Phase Separation through Sequence-Optimized Peptide Modulators

2026-02-21

Abstract excerpt

Liquid–liquid phase separation (LLPS) of intrinsically disordered proteins underlies the formation of biomolecular condensates that regulate diverse cellular processes, while its dysregulation contributes to protein aggregation and disease. Despite its importance, molecularly defined and target-specific strategies to control LLPS remain limited. Here, we present a systematic framework for designing de novo peptide...

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Literature Corpus work: cc63e95c-92be-5722-9d8c-5f6b72f5bb3b
DOI: 10.64898/2026.02.21.707152

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