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Optimizing epitope conformational ensembles using <i>α</i> -synuclein cyclic peptide “glycindel” scaffolds: A customized immunogen method for generating oligomer-selective antibodies for Parkinson’s disease

2021-09-15

Abstract excerpt

Effectively presenting epitopes on immunogens, in order to raise conformationally selective antibodies through active immunization, is a central problem in treating protein misfolding diseases, particularly neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disease. We seek to selectively target conformations enriched in toxic, oligomeric propagating species while sparing the healthy forms of th...

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Literature Corpus work
3f2d68d1-ee68-5274-8b1f-cfb5e8dd2d97
DOI
10.1101/2021.09.13.460126
Open publication

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Optimizing epitope conformational ensembles using <i>α</i> -synuclein cyclic peptide “glycindel” scaffolds: A customized immunogen method for generating oligomer-selective antibodies for Parkinson’s diseaseDOI 10.1101/2021.09.13.460126
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