Article

Spatial mitochondrial lineage tracing uncovers a premetastatic niche and microenvironment-programmed fate switching in osteosarcoma

2026-07-11

Abstract excerpt

Osteosarcoma progression involves complex spatiotemporal dynamics, yet the lineage relationships underlying tumor cell fate decisions remain poorly understood. Here we integrate single cell and spatial transcriptomics and mitochondrial variants-based lineage tracing to map the evolution of a late-stage, non-metastatic osteosarcoma. Single cell pseudotemporal reconstruction of malignant cells reveals a stepwise cas...

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Literature Corpus work: 028e2573-2ce9-57e7-8515-16f89c8e5d02
DOI: 10.64898/2026.07.09.737611

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