Article

Mapping the Single-cell Differentiation Landscape of Osteosarcoma

2023-09-14

Abstract excerpt

The genetic and intratumoral heterogeneity observed in human osteosarcomas (OS) poses challenges for drug development and the study of cell fate, plasticity, and differentiation, processes linked to tumor grade, cell metastasis, and survival. To pinpoint errors in OS differentiation, we transcriptionally profiled 31,527 cells from a tissue-engineered model that directs MSCs toward adipogenic and osteoblastic fates...

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Literature Corpus work: 3dcab12e-b16a-55c3-9d00-cb542ccad473
DOI: 10.1101/2023.09.13.555156

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